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Lekovi iz grupe benzodiazepina se ne smeju primenjivati samostalno kod depresije ili anksioznosti udružene sa depresijom, jer u tom slučaju mogu doprineti razvoju suicidalnih misli (misli o samoubistvu).

Ova vrsta lekova ukoliko se uzima veoma dugo i u velikim dozama, dovodi do stvaranje navike i zavisnosti, a samim tim dolazi do smanjenja efikasnosti.